Study of exceptional longevity shows how APOE variants affect cognitive aging in people over 90, revealing important differences from younger populations in Alzheimer's risk genetics.
Sesaminol, a lignan from sesame seeds, reduced cellular senescence in the colons of middle-aged mice exposed to alcohol, potentially through antioxidant pathways involving AhR and Nrf2 signaling.
New review identifies senescent macrophages as key orchestrators of age-related bone loss and muscle decline, disrupting tissue niches and triggering systemic consequences throughout the skeleton.
Chronic light-dark cycle disturbances impaired multiple health metrics in aging male mice without affecting overall survival, revealing a disconnect between longevity and healthy aging.
Scientists identified LncAAT, a long noncoding RNA that mediates vascular endothelial senescence by disrupting cellular energy metabolism—offering a potential therapeutic target for age-related vascular disease.
Researchers found that Orb2, a functional amyloid essential for memory, undergoes age-dependent structural changes in Drosophila that contribute to cognitive decline—a finding with implications for understanding brain aging.
A comprehensive review in Neuron examines how menopause triggers neurobiological changes that affect brain aging and significantly increase Alzheimer's disease risk in women.
Scientists identified 8-oxoGTP, an oxidized form of a cellular building block, as a driver of neuroinflammation and accelerated cognitive decline, pointing to a novel therapeutic target.
A novel nanovaccine approach selectively eliminates senescent dendritic cells, improving metabolic dysfunction in aging—demonstrating that immune system rejuvenation can have body-wide benefits.
A double-blind, placebo-controlled trial found that blueberry consumption increased cerebral blood flow and boosted brain glutathione levels in older adults, suggesting tangible neuroprotective benefits.
New research in Nature Aging shows statins trigger bone-building pathways in skeletal stem cells during estrogen deficiency, suggesting a repurposing opportunity for postmenopausal osteoporosis beyond their cholesterol-lowering effects.
Richard Miller's perspective in The EMBO Journal critiques widespread conceptual errors hampering aging research progress, offering a framework for more rigorous thinking about interventions and mechanisms.
A comprehensive review explores how transplanting healthy mitochondria into damaged cells could treat age-related diseases by restoring both cellular energy and regulating metabolism and immunity.
New study shows exercise moderates age-related cognitive decline in midlife women, with specific improvements in processing speed and working memory—two key markers of brain health.
Large U.S. study reveals different vitamin E variants have distinct mortality benefits in older adults—alpha-tocopherol protects against cancer death while gamma-tocopherol reduces Alzheimer's mortality.
Review examines how artificial intelligence-powered biological age assessments are transitioning from research tools to clinical applications, with implications for personalized healthcare and longevity interventions.
New review examines unique cardiovascular characteristics of people who live past 100, offering insights into exceptional heart health and longevity mechanisms.
Genome-wide analysis reveals shared genetic variants between severe psychiatric disorders and biological aging biomarkers, suggesting common molecular pathways.
Novel biomaterial clears senescent macrophages through ferroptosis, promoting bone regeneration in aged animals—a potential strategy for age-related bone loss.
Autopsy study reveals sex-specific patterns: declining blood pressure in late life associates with different types of brain vascular pathology in men versus women, complicating treatment guidelines.