The Itabashi Longitudinal Study finds direct association between whole-blood NAD+ concentrations and frailty status in community-dwelling older adults, supporting NAD+ as a clinically relevant biomarker.
Study reveals APOE2—the rare gene variant linked to exceptional longevity—enhances brain pericyte health and dramatically reduces lipid droplet accumulation, offering mechanistic insight into protective aging.
Mouse research shows radiation therapy triggers heart rhythm problems through cellular senescence, but dasatinib/quercetin senolytic combination blocks this pathway and prevents atrial fibrillation development.
Study of US adults finds duration of smoking cessation correlates with improved epigenetic aging markers, suggesting DNA methylation changes from smoking may be at least partially reversible.
Review article explores emerging evidence that GLP-1 receptor agonists like semaglutide might influence biological aging beyond their established metabolic benefits, with implications for healthspan extension.
Nature Aging study maps previously hidden microproteins in the human frontal cortex, identifying novel molecular players that may contribute to Alzheimer's pathology and represent new therapeutic avenues.
A new study finds an association between hearing impairment and regional brain amyloid deposition in people during late middle age, suggesting hearing loss may be an early marker of Alzheimer's pathology.
Large-scale protein analysis identifies specific inflammatory markers that predict biological aging, multimorbidity, and mortality risk, offering potential targets for intervention and personalized health monitoring.
New research using a composite biomarker index demonstrates that caloric restriction measurably slows biological aging in older adults, providing concrete evidence for this long-studied longevity intervention.
A new review proposes that flu shots may reduce age-related inflammation not just by preventing disease, but through a novel immune training mechanism that could protect against multiple age-related conditions.
Research demonstrates that mitochondrial DNA alterations in muscle progenitor cells impair muscle fiber differentiation and overall skeletal muscle structure, revealing a mechanism behind age-related muscle decline.
Researchers identified distinct metabolites associated with the brain-healthy MIND diet in older adults, potentially revealing how this dietary pattern protects cognitive function at the molecular level.
Swedish cohort study combining family history with polygenic scores reveals how inherited longevity relates to aging markers and health trajectories in older adults.
Single-cell mapping of the locus coeruleus links APOE genetics and neuromelanin pigment to Alzheimer's vulnerability in this critical early-affected brain region.
Review explores TERT's expanding role beyond telomere maintenance, revealing how this enzyme coordinates multiple pathways critical for neuronal function and cognitive resilience.
Scientists developed DLMEH, a D-amino acid-based compound that activates mTORC1 through Sestrin2 to restore muscle protein synthesis in sarcopenia, offering a novel nutritional approach to age-related muscle loss.
Researchers found that blocking the immune checkpoint protein PD-L2 prevents senescent cell accumulation and associated tissue dysfunction, offering a potential new approach to combat aging beyond current senolytics.
A pilot human trial found rapamycin increased cerebral blood flow and favorably altered metabolic, inflammatory, and microbiome profiles in healthy middle-aged people carrying the APOE4 Alzheimer's risk gene.
First genome-wide evidence that caloric restriction—the most robust lifespan-extending intervention—directly lowers somatic mutation accumulation in mammals, a key driver of aging and cancer.
Comprehensive analysis of randomized trials identifies which specific exercise modalities most effectively prevent bone loss in middle-aged and older adults—a major public health concern.